Application of cidofovir in the treatment of adenovirus infection
10.3760/cma.j.cn112866-20240226-00029
- VernacularTitle:西多福韦在腺病毒感染治疗中的应用
- Author:
Wenbo WANG
1
;
Jing HU
;
Yuan LIU
Author Information
1. 西部战区总医院疾病预防控制科，成都 610083
- Keywords:
Adenovirus;
Infection;
Severe disease;
Cidofovir;
Nucleoside analogues
- From:
Chinese Journal of Experimental and Clinical Virology
2024;38(3):364-368
- CountryChina
- Language:Chinese
-
Abstract:
Adenovirus is a group of double-stranded DNA virus, which can cause infections of respiratory tract, gastrointestinal tract, eye, kidney and other organs. Adenovirus infection is generally self-limited disease, while in some patients progresses to high fever, dyspnea, respiratory failure and other serious infection or disseminated infection. At present, there are no approved drug for human adenovirus infection. This review summarized the clinical application of cidofovir in the treatment of adenovirus infection, including adult severe adenovirus infection, child adenovirus infection, organ transplantation infection, derivative compounds. In general, cidofovir has a certain role in the treatment of severe adenovirus infection, but most studies have small sample sizes and lack prospective cohort studies, which should be considered in future clinical studies. In addition, the development of derivative compounds or similar drugs based on cidofovir to reduce its renal toxicity is also the focus of future research.
