Update on the development of strategies for vaccine research inducing broadly neutralizing antibodies against HIV

VernacularTitle:诱导HIV广谱中和抗体的疫苗研究策略进展
Author: Xiangyu ZHANG ¹ ; Yong GAO
Author Information

1. 中国科学技术大学生命科学与医学部附属第一医院感染病科，合肥　230001
Keywords: Human immunodeficiency virus; Acquired immunodeficiency syndrome; Neutralizing antibody; Vaccine
From: Chinese Journal of Experimental and Clinical Virology 2024;38(2):209-216
CountryChina
Language:Chinese
Abstract: Acquired immunodeficiency syndrome (AIDS), a disease caused by human immunodeficiency virus (HIV), has plagued human being for nearly 40 years and continues to pose a significant challenge to our society. Development of an effective vaccine against HIV is still the most ideal approach for AIDS elimination. However, to date, no effectively preventive HIV vaccine has emerged for widespread use. HIV is a highly variable virus, and traditional vaccine strategies have encountered difficulties in preventing HIV infection. Consequently, there is a growing emphasis in the scientific community on the development of a novel vaccine capable of eliciting broadly neutralizing antibodies (bNAb) against multiple HIV variants. This article outlines the current progress in the design of new immunogens and candidate vaccines, highlighting recent clinical trials and preliminary research. It also offers insights into future directions for HIV vaccine development.