Research progress in life cycle and antiviral drugs for severe fever with thrombocytopenia syndrome virus

VernacularTitle:SFTSV感染周期和抗病毒药物的研究进展
Author: Tiezhu LIU ¹ ; Mifang LIANG ; Shiwen WANG
Author Information

1. 中国疾病预防控制中心病毒病预防控制所　国家卫生健康委员会医学病毒和病毒病重点实验室，北京　102206
Keywords: Severe fever with thrombocytopenia syndrome virus; Life cycle; Antiviral drug
From: Chinese Journal of Experimental and Clinical Virology 2022;36(4):475-480
CountryChina
Language:Chinese
Abstract: Severe fever with thrombocytopenia syndrome virus (SFTSV), is a tick-borne novel Bunyavirus, which was first discovered in the area of Dabie Mountain in China. It can cause severe fever and thrombocytopenia clinically, with a fatality rate of 10% to 30%. As the pathogenesis and infection mechanism of SFTSV are still unclear, there are no specific drugs and vaccines for SFTSV. In this paper, the mechanism of entry, replication, assembly and budding of SFTSV is reviewed, and the research progress of the treatment antibody and antiviral drugs of SFTSV is summarized, which will provide reference for the development of vaccines and antiviral drugs for SFTSV in China.