Research progress in γδ T cells in human immunodeficiency virus infection and its treatment
10.3760/cma.j.cn112866-20210812-00145
- VernacularTitle:γδ T细胞在人类免疫缺陷病毒感染及治疗中的研究进展
- Author:
Ruojing BAI
1
;
Shiyun LYU
;
Lili DAI
;
Hao WU
;
Zhen LI
Author Information
1. 首都医科大学附属北京佑安医院感染中心 艾滋病研究北京市重点实验室，北京 100069
- Keywords:
γδ T cells;
Human immunodeficiency virus;
Immunotherapy
- From:
Chinese Journal of Experimental and Clinical Virology
2022;36(3):361-365
- CountryChina
- Language:Chinese
-
Abstract:
γδ T cells are a unique type of natural immune cells that recognize antigens without the limitation of the major histocompatibility complex (MHC). They are of great significance in anti-infection immunity, serving as the important defense for maintaining immune homeostasis. Human immunodeficiency virus (HIV) infection induces the imbalance of γδ T cell subsets. A long-term antiretroviral therapy (ART) significantly damages the number and function of γδ T cells, eventually result ing in disease progression and immune reconstitution of HIV-infected patients. In the present study, we aimed to review the phenotypic function of γδ T cells, the biological role of γδ T cells in HIV infection, and γδ T cell-based immunotherapy.
