Plasmacytoid dendritic cell function and pathogenesis of chronic viral hepatitis B
10.3760/cma.j.cn112866-20200830-00233
- VernacularTitle:慢性乙型病毒性肝炎发病与浆细胞样树突状细胞功能
- Author:
Weihua CAO
1
;
Yuanjiao GAO
;
Wei YI
;
Minghui LI
;
Yao XIE
Author Information
1. 首都医科大学附属北京地坛医院肝病二科，北京 100015
- Keywords:
Plasmacytoid dendritic cells;
Hepatitis B virus;
Chronic hepatitis B;
Immunity
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(5):599-604
- CountryChina
- Language:Chinese
-
Abstract:
After hepatitis B virus (HBV) infects the body, HBV clearance and liver damage mediated by host immune response play a key role in clinical outcome. In chronic hepatitis B, the inflammatory response is a characteristic manifestation of the host immune response. The long-term inflammation promotes the development of liver fibrosis and cirrhosis. Innate immunity is the host’s first line of defense against hepatitis B virus infection, and plasmacytoid dendritic cells (pDCs) are a vital part of innate immunity and play a key role in chronic HBV infection, hepatitis occurrence, HBV clearance and recovery of infection. Exploring the function of plasmacytoid dendritic cells in chronic hepatitis B virus infection may provide a theoretical basis for clinical practice. In this article the research progress of the role of pDCs in the pathogenesis of chronic hepatitis B is reviewed.
