Progress and analysis of 2019 novel coronavirus vaccine research and development
10.3760/cma.j.cn112866-20201029-00275
- VernacularTitle:新型冠状病毒疫苗研发进展与分析
- Author:
Yaomin LIANG
1
;
Zhengfang LIN
;
Xiaoyun YANG
;
Zhongfang WANG
Author Information
1. 广州医科大学金域检验学院 510180
- Keywords:
2019 novel coronavirus;
Vaccine;
Immunity;
Antibody;
T cells
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(3):349-356
- CountryChina
- Language:Chinese
-
Abstract:
To compare the representative novel coronavirus vaccine in the world at present and to provide a new and more comprehensive reference for the research and development of novel coronavirus vaccine. This review summarized the virological and immunological basis of novel coronavirus vaccine and made a detailed comparison and analysis of some representative vaccines based on different technologies and clinical trials in phase 2a/3. The immune effect of many kinds of novel coronavirus vaccines in phase 3 clinical trials around the world is encouraging, but the relationship between vaccine immunogenicity and safety and the reliability of clinical trial data still need to be paid close attention to. Designing new vaccine targets, inducing more extensive immune protection, improving immunogenicity, strict clinical trials and establishing large-scale cohort studies are higher requirements for novel coronavirus vaccine research and development.
