Investigation of pathogen spectrum of virus in acute respiratory infection in Fuzhou in 2019
10.3760/cma/j.cn112866-20200911-00240
- VernacularTitle:2019年福州市急性呼吸道感染病例病毒病原谱调查
- Author:
Sixian LIN
1
;
Libin YOU
;
Yanhua ZHANG
;
Ying ZHU
;
Tingting YU
;
Yuwei WENG
;
Kuicheng ZHENG
Author Information
1. 福建医科大学公共卫生学院，福州 350122
- Keywords:
Acute respiratory infection;
Virus;
Pathogen;
Epidemiology
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(2):188-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify the viral etiologies and epidemic characteristics of acute respiratory infection (ARI) in Fuzhou.Methods:The information and respiratory tract specimens of ARI cases from three different types of hospitals in Fuzhou were collected in 2019. Real-time quantitative fluorescent PCR (Polymerase Chain Reaction, PCR) was uesd to detect adenovirus (AdV) and human bocavirus (HBoV), Real-time quantitative fluorescent RT-PCR (Reverse Transcription-PCR, RT-PCR) was used to detect influenza virus A/B (IFV-A/B), respiratory syncytial virus (RSV), parainfluenza virus 1-4 (PIV-1~4), human metapneumovirus (HmpV), coronavirus (CoV)-229E/OC43/HKU1/NL63 and rhinovirus (RV). Chi-square test and Fisher exact test were used to analyze the epidemiological characteristics of ARI cases. Results:Of the 726 ARI cases enrolled, 316 (43.53%) were positive for at least one viral pathogen, of which, 40 cases had dual infection and 9 had triple infection. The viral infection rates in different age groups were significantly different. The main viral pathogens in ARI in Fuzhou in 2019 were IFVs (12.40%), followed by Adv (10.61%), RV (8.82%), and RSV (5.51%). The AdV infection was more common in male ARI cases, and IFV-B, PIV, RSV, RV, and AdV were identified more commonly in children. In addition, the infection with IFVs, RSV, and RV had obvious seasonality.Conclusions:The main pathogens of ARI cases in Fuzhou in 2019 include IFVs, AdV, RV, RSV, etc. The infection of respective virus in ARI cases represent different age-distribution and seasonality.
