Study on the antibodies and viral load of HIV-1 infected individuals with different immune status
10.3760/cma.j.cn112866-20200902-00235
- VernacularTitle:HIV-1感染者不同免疫状态的抗体及病毒载量研究
- Author:
Qianru LIN
1
;
Hejun YU
;
Hui ZHANG
;
Guiying LI
;
Yanming SUN
;
Min YANG
;
Xiaomei JIN
;
Liying MA
;
Cong JIN
;
Yao XIAO
Author Information
1. 中国疾病预防控制中心性病艾滋病预防控制中心，北京 102206
- Keywords:
HIV-1;
CD4;
WB;
S/CO;
Combined indicators
- From:
Chinese Journal of Experimental and Clinical Virology
2021;35(2):147-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the differences in virological and immunological indicators of HIV-1 infected individuals with different degrees of immunosuppression, analyze the correlation between the sample/cutoff ratio (S/CO), viral load (VL), Western blot (WB) band type and immune status of HIV-1 infected individuals.Methods:A total of 639 HIV-1 antibodies positive and treatment-naive samples from Henan, Beijing and Yunnan during the period of 2017-2019 were divided into three groups: no immunosuppression (CD4≥500 cells/μl), mild immunosuppressive (350cells/μl≤CD4<500cells/μl), moderate immunosuppression (200 cells/μl≤CD4<350 cells/μl), severe immunosuppression (CD4<200 cells/μl). Chi-square test was used to compare S/CO, WB band type among different immunosuppression groups, analyze the relationship between various indicators and immune status.Results:In each immunosuppressive group, S/CO>20 had the highest occurrence rate (>37%), and showed a decreasing trend with the enhancement of immunity ( P<0.05), the occurrence rate of 1
19%), the occurrence rate of 078%), while the occurrence rates of p55 (<40%) and p39 (<3%) were the lowest, the differences of the occurrence rates of gp41 and p51 among different immunosuppression groups were statistically significant ( P<0.05). The area under the curve determined by S/CO value combined with viral load for no, mild, moderate and severe immunosuppression groups were respectively 0.651 (95% CI: 0.600-0.702; P<0.05), 0.587 (95% CI: 0.540-0.635; P<0.05), 0.605 (95% CI: 0.560~0.650; P<0.05), 0.647 (95% CI: 0.586-0.708; P<0.05). Conclusions:The S/CO value viral load was the best for the determination of non-immunosuppressive status; The absence of gp41 and p51, S/CO>20 suggest that the patient may be in non or severe immunosuppressed state, respectively.
