Research progress in human bocavirus 1 infections in children
10.3760/cma.j.cn112866-20200213-00021
- VernacularTitle:儿童人博卡病毒1型感染研究进展
- Author:
Jing LIAO
1
;
Na ZANG
;
Enmei LIU
Author Information
1. 重庆医科大学附属儿童医院呼吸科 国家儿童健康与疾病临床医学研究中心 400014
- Keywords:
Human bocavirus 1;
Epidemiology;
Pathogenic mechanism;
latent infection;
Detection
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(6):677-682
- CountryChina
- Language:Chinese
-
Abstract:
Human bocavirus 1 (HBoV1) is one of the most important pathogenic viruses in children with severe lower respiratory tract infections, which can cause pneumonia and bronchiolitis. HBoV1 DNA can persist in nasopharyngeal secretions after acute infection for several months, establish latent infection to promote the occurrence of pulmonary fibrosis. Consequently, mere qualitative PCR is not an adequate method for diagnosing HBoV1 infections accurately. It must be combined with quantitative PCR and serology. This review makes a comprehensive summary on the virological characteristics, epidemiological characteristics, pathogenesis and diseases caused by HBoV1 infections, detection and diagnosis of HBoV1, and looks forward to its main further research direction.
