Etiological surveillance and genotype of hand, foot and mouth disease in Liaoning province in 2018
10.3760/cma.j.cn112866-20190916-000145
- VernacularTitle:2018年辽宁省手足口病病原学特征及主要病原基因分型
- Author:
Lu LEI
1
;
Wei YU
;
Qian ZHANG
;
Ling WANG
;
Lingling MAO
;
Yingwei SUN
;
Wenqing YAO
Author Information
1. 辽宁省疾病预防控制中心，沈阳 110005
- Keywords:
Hand, foot and mouth disease;
Enterovirus;
Etiology;
Genotype
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(5):495-499
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the etiological constituents of hand, foot and mouth disease (HFMD) in Liaoning province, and analyze genetic characteristics of coxsackievirus A (CA)6 and CV-A10 to provide evidences for the prevention and control of HFMD.Methods:A total of 4 744 HFMD clinical specimens of Liaoning province in 2018 had been detected for enterovirus by RT-PCR And 688 positive specimens were chosen for viral culture isolation. Then 6 CV-A6 isolates and 10 CV-A10 isolates were selected for the nucleotide sequence determination of specific VP1 gene.Results:The age distribution was mainly in the 1-4 years old group and occurred in July and August. There were 3 161 enterovirus-positive samples in 4 744 clinical specimens, the positive rate was 66.63%, mainly the other enterovirus (86.68%). In 2018, the predominant pathogens of HFMD in Liaoning province were mainly CV-A6. The sequencing and comparison of pathogenicity of HFMD showed that CV-A6 were D3 subtype, CV-A10 were C.Conclusions:HFMD in Liaoning province wa mainly prevalent among children under 4 years of age. The peak of onset occurred in the summer. The main pathogen was CV-A6.
