Research advances in the mechanisms of HIV-related atherosclerotic cardiovascular disease
10.3760/cma.j.cn112866-20190823-00129
- VernacularTitle:HIV相关动脉粥样硬化性心血管疾病的发病机制研究进展
- Author:
Huan XIA
1
;
Zhongfang YAN
;
Bin SU
;
Hao WU
;
Ping MA
Author Information
1. 南开大学附属第二人民医院感染二科，天津 300192
- Keywords:
Human immunodeficiency virus;
Atherosclerotic cardiovascular disease;
Mechanism
- From:
Chinese Journal of Experimental and Clinical Virology
2020;34(3):337-340
- CountryChina
- Language:Chinese
-
Abstract:
The development and implementation of antiretroviral therapy (ART) has transformed human immunodeficiency virus (HIV) infection into a controllable chronic condition. HIV infection can cause potential cardiovascular complications and increase the risk of cardiovascular disease along with myocardial infarction, stroke, peripheral arterial disease, sudden cardiac death, and heart failure. However, the pathogenesis of atherosclerosis in the setting of HIV infection is complex and unclear. In this review, we discuss the mechanisms of HIV-associated atherosclerotic cardiovascular disease, including the effects of the viral proteins on immune and vascular cells, the immunodeficiency caused by the HIV infection, co-infection with cytomegalovirus (CMV), microbial translocation, chronic inflammation and immune activation, and a few ART-related mechanisms.
