Expression of arginase Ⅰ in peripheral superficial lymph node of HIV-infected individuals
10.3760/cma.j.issn.1003-9279.2015.01.015
- VernacularTitle:精氨酸酶Ⅰ在HIV感染者外周浅表淋巴结中表达的研究
- Author:
Naichun ZHANG
1
;
Lei HUANG
;
Songshan WANG
;
Jianning DENG
;
Xiangchan LU
;
Fengyao WU
;
Min ZHAO
Author Information
1. 100191 北京大学医学部
- Keywords:
Arginase;
Acquired immunodeficiency syndrome;
Lymph nodes;
Immunohistochemistry
- From:
Chinese Journal of Experimental and Clinical Virology
2015;29(1):44-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of arginase Ⅰ (.Arg Ⅰ) in peripheral superficial lymph nodes of HIV-infected individuals and to explore their correlation with HIV/AIDS disease progression.Methods All the patients were divided to two groups according to the CD4 + T cell counts in peripheral blood,immunohistochemistry was used to detect expression of Arg Ⅰ in peripheral superficial lymph node of non HIV-infected and HIV-infected individuals.The data were statistically analyzed with SPSS17.0.Results Levels of Arg Ⅰ expression in peripheral superficial lymph node of HIV-infected individuals were higher than those of non HIV-infected lymph nodes (P ＜ 0.01).The expressions of Arg Ⅰ in patients with AIDS in different CD4 + T lymphocyte counts were distinct.Levels of Arg Ⅰ expression in peripheral superficial lymph nodes of CD4 + T lymphocyte counts ≥350/ μl and 200/ μl ≤ CD4 + T lymphocyte counts ＜ 350/ μl AIDS patients had no significant difference (P ＞ 0.05),while there was significant difference between expression of Arg Ⅰ in CD4 + T lymphocyte counts ≥ 350/ μl,200/ μl ≤ CD4 + T lymphocyte counts ＜ 350/ μl and CD4 + T lymphocyte counts ＜ 200/ μl AIDS patients (P ＜ 0.05).In addition,statistical analysis of the above results showed that CD4 +T cell counts in peripheral blood were negatively correlated with expression level of Arg Ⅰ.Conclusions Levels of Arg Ⅰ expression in peripheral superficial lymph node of AIDS patients were significantly high and associated with disease progression.
