Cross-sectional analysis on drug resistance profile of acquired immune deficiency syndrome patients receiving a long-term antiretroviral treatment in Henan
10.3760/cma.j.issn.1003-9279.2012.03.003
- VernacularTitle:河南省长期接受抗病毒治疗的艾滋病患者耐药横断面分析
- Author:
Wei-Guo CUI
1
;
Jia LIU
;
Xiu-Juan XUE
;
Guo-Qing SUN
;
Sui-An TIAN
;
Chun-Hua LIU
;
Yao-Wu CHENG
;
Qi LI
;
Zhe WANG
Author Information
1. 河南省疾病预防控制中心
- Keywords:
Acguired immunodeficiency syndrome;
Drug resistence;
Antiviral agents;
Crosssectional studies
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(3):168-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the condition of drug resistance among acquired immune deficiency syndrome (AIDS) patients with a long-term antiretroviral treatment in Henan province,provide some useful data for such patients to continue effective treatment.Method Patients beginning first-line antiretroviral treatment before and after 2004 were selected in two counties of Henan.CD4+ T cells,virus load and genotypic resistance(In-house) were tested.Results A total of 164 patients were selected in two counties,with a median (interquartile range,IQR) CD4+T cells 398.00 (242.00-489.50 )cells/μl,32.32％ of the patients had a virus load lower than the lowest detected level.Ninety-five patients had a virus load more than 1000 copies/ml,77 of them completed the drug resistance test,drug resistance mutations occurred in 68.83％,the NNRTIs and NRTIs mutations were found in 64.94％ and 55.84％ of them,respectively,no PIs mutations were detected. K103N/S (44.16％) was the most frequent NNRTIs mutations that have occurred,followed by G190A/S (19.48％) and Y181C/V (14.29％ ).Thymidine analogue mutations (TAMs) was the most common NRTIs mutations that have occurred,≥1TAM accounted for 46.75％,TAM-1/TAM-2 accounted for 24.68％.M184V/I was also the NRTIs mutations.Among the 77 patients,the proportion of patients who had resistance to the NRTIs:ddI,3TC,AZT,D4T and TDF was 50.65％,33.77％,48.05％,50.65％ and 46.75％ respectively,the proportion of patients who had resistance to the NNRTIs:EFV,NVP and DLV was 64.94％,64.94％ and 62.34％,respectively.Conclusion The situation of drug resistance among AIDS patients treated with a long-term antiretroviral treatment in Henan province was serious,more attention and timely treatment adjustment are needed to such patients with AIDS.
