Association of various levels of blood pressure and related factors with all-cause death in Hainan centenarians: a prospective cohort study
10.3760/cma.j.cn112338-20220414-00294
- VernacularTitle:海南百岁老人血压水平及相关因素与全因死亡关联的前瞻性队列研究
- Author:
Xuehang LI
1
;
Jing LI
;
Shengshu WANG
;
Yang SONG
;
Shaohua LIU
;
Shimin CHEN
;
Zhiqiang LI
;
Rongrong LI
;
Haowei LI
;
Shanshan YANG
;
Jianhua WANG
;
Yali ZHAO
;
Qiao ZHU
;
Chaoxue NING
;
Miao LIU
;
Yao HE
Author Information
1. 解放军总医院第二医学中心老年医学研究所，衰老及相关疾病研究北京市重点实验室，国家老年疾病临床医学研究中心，北京 100853
- Keywords:
Centenarian;
Blood pressure;
All-cause death;
Body mass index
- From:
Chinese Journal of Epidemiology
2023;44(1):115-121
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the associations of various levels of systolic and diastolic blood pressure levels and related factors with all-cause death in the centenarians in Hainan Province.Methods:The data were obtained from China Hainan Centenarian Cohort Study, a prospective cohort study which included 1 002 centenarians. Cox proportional risk regression models were used to analyze the associations of blood pressure and related factors with all-cause death in the centenarians.Results:As of May 31, 2021, with the median of the follow-up time of 4.16 years, and the mortality density had reach 15.24 per 100 person-years. After grouping by SBP and DBP quartiles, the Q1 of SBP and Q2 of DBP caused the lowest mortality density (12.73 per 100 person-years and 14.10 per 100 person-years relatively). In all the centenarians, compared with the Q1 of SBP (≤137 mmHg, 1 mmHg=0.133 kPa), Q2, Q3 and Q4 were all positively associated with all-cause death. In the female population, the HRs of SBP's Q2, Q3 and Q4 were 1.343, 1.355 and 1.420 respectively ( Q1 as reference), and the HRs of DBP's Q1, Q3 and Q4 were 1.468, 1.800 and 1.504 respectively ( Q2 as reference), showing a roughly U-shaped association. Interactive analysis showed multiplicative interaction between SBP and BMI. Conclusions:In the centenarians in Hainan, different levels of systolic and diastolic blood pressure were associated with all-cause death. In the centenarians, DBP might have a suitable level or range in which the risk of death is relatively low. Different BMI status might affect the associations of blood pressure levels with death outcomes.
