Association of abdominal obesity and obesity types with carotid intima-media thickness in children in China
10.3760/cma.j.cn112338-20200225-00171
- VernacularTitle:儿童腹型肥胖及其肥胖类型与颈动脉内中膜厚度的关系
- Author:
Chuanwei MA
1
;
Liu YANG
;
Min ZHAO
;
Bo XI
Author Information
1. 山东大学齐鲁医学院公共卫生学院流行病学系/山东大学儿童心血管研究中心，济南 250012
- Keywords:
Abdominal obesity;
Carotid intima-media thickness;
Children
- From:
Chinese Journal of Epidemiology
2020;41(9):1450-1454
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association of abdominal obesity and obesity types with carotid intima-media thickness (cIMT) in children and provide scientific evidence for the prevention of abnormal vascular structure.Methods:Based on the "Children’s Cardiovascular Health Cohort" conducted in Huantai county of Zibo, Shandong province from November 2017 to January 2018, a total of 1 240 children, including 657 boys (53.0%), who had completed data of sex, age, physical examinations, blood biochemical indices and lifestyle variables (collected by questionnaires) were included for the analysis. Covariance analysis was used to compare the levels of cIMT in groups with normal waist circumference, pre-abdominal obesity and abdominal obesity. Logistic regression analysis was used to evaluate the association of pre-abdominal obesity and abdominal obesity with high cIMT, and the association of combined effect of general overweight or obesity and abdominal obesity or pre-abdominal obesity with high cIMT.Results:The levels of cIMT in children with pre-abdominal obesity (0.47±0.03) mm and abdominal obesity (0.50±0.04) mm were higher than that in children with normal waist circumference (0.45±0.05) mm, the difference was significant ( P<0.001). The detection rates of high cIMT in children with pre-abdominal obesity(20.8%) and abdominal obesity (49.5%) were higher than that in children with normal waist circumference (8.8%), the difference was significant ( P<0.001). Compared with normal waist circumference, pre-abdominal obesity and abdominal obesity were significantly associated with high cIMT (pre-abdominal obesity: OR=2.53, 95 %CI: 1.67-3.84; abdominal obesity: OR=8.56, 95 %CI: 5.97-12.29) after adjustment for potential covariates. Compared with normal body mass index and normal waist circumference, abdominal obesity or pre-abdominal obesity alone ( OR=2.24, 95 %CI: 1.36-3.69), and mixed overweight and obesity ( OR=6.94, 95 %CI: 4.87-9.90) were significantly associated with high cIMT. Conclusions:The association between abdominal obesity and high cIMT was significant in children, and the association was stronger between mixed overweight or obesity and high cIMT, suggesting that we should consider mixed overweight and obesity in the prevention of abnormal vascular structure.
