Research progress of botulinum toxin A in the therapeutic applications of oral diseases
10.3760/cma.j.cn112144-20240304-00095
- VernacularTitle:A型肉毒毒素在口腔疾病治疗中的研究进展
- Author:
Xin LI
1
;
Xiaoyan FENG
;
Yiyang SHEN
;
Jun LIN
Author Information
1. 浙江大学医学院附属第一医院口腔科·口腔医学院 浙江省口腔生物医学研究重点实验室，杭州 310003
- Keywords:
Botulinum toxins;
Botulinum toxins, type A;
Oral diseases;
Therapeutic applications
- From:
Chinese Journal of Stomatology
2024;59(11):1168-1173
- CountryChina
- Language:Chinese
-
Abstract:
Botulinum toxin A (BTX-A) is a powerful neurotoxin produced by Clostridium botulinum, which can relieve muscle spasm or limit gland secretion by inhibiting the release of acetylcholine at the neuromuscular/glandular junction. In addition, BTX-A can also play a role in the sensory feedback loop, which can ease pain. Currently, dentists are paying more attention to the cosmetic applications of BTX-A in the oral and maxillofacial region, while their understanding of BTX-A′s non-cosmetic applications is still insufficient. Although the specific molecular mechanism of BTX-A in oral diseases has not been fully clarified, with the development of evidence-based medicine, more and more clinical evidence has began to support the effectiveness of BTX-A in the therapeutic applications of oral diseases. This article will briefly review the main molecular mechanisms of BTX-A, the latest clinical research progress of BTX-A at home and abroad in the treatment of oral diseases, clinical contraindications and adverse reactions of BTX-A, providing a new idea for the treatment of oral diseases.
