Dental pulp stem cells in tooth regeneration: advancement and emerging directions

VernacularTitle:牙髓干细胞用于牙再生的新进展和新方向
Author: Lin MA ¹ ; Anqi LIU ; Hao GUO ; Kun XUAN
Author Information

1. 第四军医大学口腔医院口腔预防科　口颌系统重建与再生全国重点实验室　国家口腔疾病临床医学研究中心　陕西省口腔疾病临床医学研究中心，西安　710032
Keywords: Regenerative medicine; Dental pulp stem cells; Stem cell from human exfoliated deciduous teeth; Tooth regeneration; Single-cell RNA sequencing
From: Chinese Journal of Stomatology 2024;59(5):496-501
CountryChina
Language:Chinese
Abstract: Regenerating tissues similar to dental structure with normal function are putatively to be the aim in tooth regeneration filed. Currently, researchers preliminarily achieved tooth regeneration by applying dental pulp stem cells (DPSC) and stem cells from human exfoliated deciduous teeth (SHED). However, the regeneration efficiency remains unstable and needs further investigation. The development of single-cell RNA sequencing and organoid culture system provide potential of precise, targeted and controllable functional regeneration. This article reviews the current state of DPSC/SHED on tooth regeneration, and analyzes characteristics and hotspots of them, aiming to shed light on clinical translational application of stable and efficient tooth regeneration.