Histone acetylation in the development and regeneration of craniofacial hard tissue

VernacularTitle:组蛋白乙酰化修饰在颅颌面硬组织发育和再生中的作用
Author: Xinquan JIANG ¹
Author Information

1. 上海交通大学医学院附属第九人民医院口腔修复科　上海交通大学口腔医学院　国家口腔医学中心　国家口腔疾病临床医学研究中心　上海市口腔医学重点实验室　上海市口腔医学研究所，上海　200011
Keywords: Regenerative medicine; Histone acetylation; Craniofacial hard tissue; Epigenetic regulation
From: Chinese Journal of Stomatology 2024;59(5):426-434
CountryChina
Language:Chinese
Abstract: Craniofacial hard tissue mainly includes craniofacial bone and tooth, which is one of the important parts of the mouth-jaw system. Congenital aplasia, tumors and trauma can cause large craniofacial hard tissue defects, which are detrimental to the facial appearance and function of patients, and affect the physical and mental health of patients. Histone acetylation modification is the earliest and most widely studied histone modification, which is an epigenetic modification mechanism jointly regulated by histone acetyltransferase and histone deacetylase. In this paper, we will review the research progress of histone acetylation mediated by histone acetyltransferase and histone deacetylase in the development and regeneration of craniofacial hard tissue.