Research progress on the effects of the interactions between phage and periodontal pathogens on periodontal disease
10.3760/cma.j.cn112144-20210428-00201
- VernacularTitle:噬菌体与牙周病原菌相互作用对牙周病影响的研究进展
- Author:
Zhen LIU
1
;
Zijian ZHANG
;
Ketai HE
;
Ruijie HUANG
Author Information
1. 四川大学华西口腔医院儿童口腔科 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心，成都 610041
- Keywords:
Periodontitis;
Phage;
Oral microecology;
Microbial interactions
- From:
Chinese Journal of Stomatology
2021;56(12):1282-1286
- CountryChina
- Language:Chinese
-
Abstract:
Periodontal disease is among the most prevalent oral diseases. As viruses that may infect bacteria, bacteriophages constitute an important component of the oral microbiome. With the advances in bioinformatics and genomics, the relationships among the bacteriophages, oral microbiome and periodontal disease is gradually being elucidated. As a result, phage therapy has become an emerging approach in the fight against super bacteria and has flourished in recent years. This review article discusses the mechanisms involved in the microbial interactions associated with oral phages and periodontal disease, the role of phages in maintaining a normal periodontal environment, the relationship between the imbalance of phages and the occurrence of periodontal disease, and the use of phage in the treatment of periodontal disease in order to provides references for in-depth research on the mechanisms of phage effects on periodontal disease, as well as the further clinical application of phage therapy.
