Mechanism of endoplasmic reticulum and mitochondria interference in functional dyspepsia and intervention status of Chinese medicine for Shu Gan Jian Pi
10.13699/j.cnki.1001-6821.2024.15.030
- VernacularTitle:内质网-线粒体互扰在功能性消化不良中的机制及疏肝健脾类中药的干预现状
- Author:
Jun GUO
1
;
Zheng-Quan WU
;
Zheng-Yan WANG
;
Hui-Jun ZHANG
;
Sheng-Cai LI
;
Xu-Dong TIAN
Author Information
1. 甘肃省中医院脾胃病科,甘肃兰州 730020
- Keywords:
endoplasmic reticulum stress;
mitochondrial autophagy;
functional dyspepsia;
Gan Yu Pi Xu
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(15):2292-2295
- CountryChina
- Language:Chinese
-
Abstract:
Gastrointestinal dyskinesia is a central factor contributing to the development of functional dyspepsia(FD),which is characterized by the rupture of the gastrointestinal nerve-Cajal interstitial cell-smooth muscle network.Gan Yu Pi Xu are similar to endoplasmic reticulum stress(ERs)-mitochondrial autophagy homeostasis imbalance.Mitochondrial autophagy disorders are the biological basis of Pi Xu,and Gan Yu is the macroscopic manifestation of ERs,and regulation of ERs-mitochondrial autophagy pathway is an important way to prevent and control FD.In this paper,we start from the theory of"liver-spleen correlation",combine the changes of endoplasmic reticulum and mitochondria in the process of gastrointestinal dyskinesia,reveal the correlation between the pathogenesis of Gan Yu Pi Xu and the autophagy of ERs and mitochondria,and elucidate the mechanism of gastrointestinal dyskinesia by the method of Shu Gan Jian Pi,so as to provide a new point of view for the treatment of gastrointestinal dyskinesia in FD.
