Research status of Chinese medicine in improving diabetic cardiomyopathy by regulating cellular autophagy
10.13699/j.cnki.1001-6821.2024.10.029
- VernacularTitle:中医药通过调控细胞自噬改善糖尿病心肌病的研究现状
- Author:
Lei LIU
1
;
Li-Xia YANG
;
Yong-Lin LIANG
;
Xiang-Dong ZHU
;
Yan-Kui GAO
Author Information
1. 甘肃中医药大学中医临床学院,甘肃兰州 730000
- Keywords:
traditional Chinese medicine;
diabetic cardiomyopathy;
cellular autophagy;
active ingredients;
review
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(10):1530-1534
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of diabetic cardiomyopathy(DCM)is complex.Autophagy plays a pivotal role in the development of DCM,and whether its level is stable or not is closely related to the development of the course of DCM.Numerous active components found in traditional Chinese medicines and compound formulations have demonstrated the ability to modulate autophagy levels.These interventions occur through various mechanisms,such as hypoglycemic,anti-apoptotic,anti-inflammatory,and anti-oxidative stress pathways.By mitigating autophagy-induced myocardial damage,enhancing cardiac function,and slowing the progression of DCM,these compounds offer promising avenues for DCM management.This paper aims to consolidate and present research findings from the last 5 years.Our goal is to provide valuable insights and references for the research,development,and clinical application of Chinese medicine in the context of combating DCM.
