Research status of traditional Chinese medicine intervening JAK/STAT signaling pathway to prevent and treat diabetes and its chronic complications

VernacularTitle:中药干预JAK/STAT信号通路防治糖尿病及其慢性并发症的研究状况
Author: Tao LI ¹ ; Li-Xia YANG ; Bo GAO ; Qin LI ; Shuang SONG
Author Information

1. 甘肃中医药大学中医临床学院,甘肃兰州 730000
Keywords: chronic complications of type 2 diabetes; Janus kinase/signal transduction and transcriptional activator signaling pathway; traditional Chinese medicine
From: The Chinese Journal of Clinical Pharmacology 2024;40(5):754-758
CountryChina
Language:Chinese
Abstract: Type 2 diabetes mellitus(T2DM)and its chronic complications are the main causes of disability and death in diabetic patients.Traditional Chinese medicine has the advantages of significant curative effect and low recurrence rate.In recent years,the basic research on the treatment of T2DM with traditional Chinese medicine has made significant progress,and its mechanism may be related to the regulation of Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signal pathway by traditional Chinese medicine.This paper expounds the relationship between JAK/STAT signaling pathway and T2DM,and summarizes the research progress of traditional Chinese medicine extract and compound prescription in the intervention of T2DM by regulating this signaling pathway,in order to provide references for the clinical application of T2DM therapeutics and the development of new drugs.