Analysis of the research status of AA-CYP-HETE/EETs metabolic pathways and cardiovascular disease therapeutic drugs
10.13699/j.cnki.1001-6821.2024.04.030
- VernacularTitle:AA-CYP-HETE/EETs代谢通路与心血管疾病治疗药物研究现状的分析
- Author:
Ming-Xia HU
1
;
Yong-Yun HE
;
Yue YAO
;
Xiao-Dan MO
;
Xiu-Fen YANG
Author Information
1. 广西中医药大学药学院,广西壮族自治区 南宁 530200;广西中医药大学广西壮瑶药重点实验室,广西壮族自治区 南宁 530200;广西中医药大学广西高校中药神经-代谢及免疫药理重点实验室,广西壮族自治区 南宁 530200
- Keywords:
arachidonic acid;
cytochrome P450;
20-hydroxyeicosatetraenoic acid;
epoxyeicosatrienoic acid;
cardiovascular disease
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(4):619-623
- CountryChina
- Language:Chinese
-
Abstract:
20-hydroxyeicosatetraenoic acid(20-HETE)and epoxyeicosatrienoic acids(EETs)are products of enzyme metabolism of arachidonic acid(AA)by cytochrome P450(CYP).20-HETE is mainly produced by CYP4A,CYP4F metabolism of AA,which has a certain toxic effect on the cardiovascular and cerebrovascular system.EETS is mainly produced by CYP2J,CYP2C metabolizes AA,which has a certain protective effect on the cardiovascular and cerebrovascular system.This article reviews the effects and mechanisms of drugs related to AA-CYP-HETE/EETs metabolic pathway on cardiovascular diseases such as myocardial hypertrophy,hypertension,heart failure,and myocardial infarction,in order to provide a reference for the clinical use of cardiovascular diseases and provide ideas and directions for the basic research and development of cardiovascular disease treatment drugs.
