Clinical study on the curative effect of indobufen combined with clopidogrel in patients with acute myocardial infarction after PCI
10.13699/j.cnki.1001-6821.2024.04.004
- VernacularTitle:吲哚布芬联合氯吡格雷对急性心肌梗死患者PCI术后疗效的临床研究
- Author:
Hui CHENG
1
;
Jie-Cheng PENG
;
Wan-Shi WU
;
Xing-Bing HU
;
Jia-Feng SU
Author Information
1. 安徽医科大学附属安庆第一人民医院心血管内科,安徽安庆 246000
- Keywords:
indobufen;
clopidogrel;
acute myocardial infarction;
percutaneous coronary intervention;
curative effect;
platelet activity;
coagulation function
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(4):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the curative effect of indobufen combined with clopidogrel and its influences on platelet activity and coagulation function in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods According to different treatment methods,patients with AMI were divided into treatment group and control group.The control group was given clopidogrel(75 mg,qd)and aspirin(0.1 g,qd),while treatment group was given clopidogrel(75 mg,qd)and indobufen tablets(0.1 g,bid).All were treated for 1 month.The curative effect,platelet count(PLT),mean platelet volume(MPV),prothrombin time(PT),fibrinogen(FIB)and D-dimer(D-D)before and after treatment,and adverse events within 1 month after medication were compared between the two groups.Results There were 38 cases in treatment group and 43 cases in control group.After treatment,curative effect in treatment group and control group were 97.37％and 86.05％,PLT were(167.89±43.62)× 109·L-1 and(183.73±49.81)× 109·L-1,MPV were(11.86±2.31)and(10.97±2.16)fl,FIB levels were(2.53±0.61)and(2.78±0.72)g·L-1,D-D levels were(0.20±0.06)and(0.22±0.07)mg·L-1,PT were(12.82±2.35)and(12.26±2.28)s,the difference was not statistically significant(all P＞0.05).The incidence of adverse drug reactions in treatment group and control group were 2.63％and 11.63％,and the difference was statistically significant(P＜0.001).Conclusion Indobufen combined with clopidogrel has the comparable curative effect and good anti-platelet aggregation effect as aspirin,and indobufen has higher safety.So it is recommended as the medication regimen for AMI patients after PCI.
