Gastroesophageal reflux disease and chronic obstructive pulmonary disease:Two samples Mendelian randomization study
10.13699/j.cnki.1001-6821.2024.03.028
- VernacularTitle:胃食管反流病与慢性阻塞性肺疾病:两样本孟德尔随机化研究
- Author:
Lu ZHANG
1
;
Na GUO
;
Hong GUO
;
Jian LIU
Author Information
1. 兰州大学第一临床医学院,甘肃兰州 730000
- Keywords:
gastroesophageal reflux disease;
chronic obstructive pulmonary disease;
Mendelian randomization study
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(3):440-443
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the causal relationship between gastro esophageal reflux disease(GERD)and chronic obstructive pulmonary disease(COPD)by a two-sample Mendelian randomization method.Methods From the summary data of genome-wide association studies(GWAS),single nucleotide polymorphisms(SNP)associated with GERD were selected as genetic instrumental variables.The primary analysis employed the inverse variance weighted(IVW)method for estimating causal effects,with MR-Egger,weighted median,simple mode,and weighted mode methods as supplementary approaches.Sensitivity analyses were conducted to assess the robustness of the results,including Cochran's Q test,MR-Egger intercept,and leave-one-out analysis.Results There might be an association between GERD and an increased risk of COPD[IVW:odds ratio(OR)=1.80,95％confidence interval(CI)1.55-2.08,P＜0.01].Furthermore,no evidence of horizontal pleiotropy and heterogeneity was observed through MR-Egger intercept,Cochran's Q test,and leave-one-out analysis.Conclusion GERD can increase the risk of COPD,and aggressive control of GERD is recommended to reduce the incidence of COPD.
