Clinical application and evaluation of marketed nucleic acid drugs at home and abroad
10.13699/j.cnki.1001-6821.2023.24.029
- VernacularTitle:国内外上市核酸药物的临床应用与评价
- Author:
Yi-Long YAN
1
;
Zhi-Gang ZHAO
Author Information
1. 首都医科大学附属北京天坛医院药学部,北京 100070;首都医科大学药学院临床药学系,北京 100069
- Keywords:
nucleic acid drugs;
antisense oligonucleotides;
small interfering RNA;
messenger RNA
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(24):3677-3681
- CountryChina
- Language:Chinese
-
Abstract:
With the development of molecular biology technology,nucleic acid drugs are gradually becoming an emerging targeted therapeutic means.The types of nucleic acid drugs with more varieties currently on the market at home and abroad are antisense oligonucleotides and small interfering RNAs,and the indications are mainly for rare diseases such as duchenne muscular dystrophy,spinal muscular atrophy and acute hepatic porphyria.With the rapid progress in the development of messenger RNA drugs since the outbreak of novel coronavirus pneumonia in 2019,new breakthroughs have been generated.Based on the background and development history of nucleic acid drugs,the clinical application and evaluation of the above three types of nucleic acid drugs were reviewed in this paper,so as to provide reference for rational use of nucleic acid drugs.
