Research status of protection of important organs by esketamine
10.13699/j.cnki.1001-6821.2023.24.027
- VernacularTitle:艾司氯胺酮对重要器官保护研究现状
- Author:
Sen LI
1
;
Jin-Xin LAN
;
Duo YANG
;
Jun-Bing HE
;
Long-Sheng ZHANG
Author Information
1. 广东医科大学第一临床医学院,广东湛江 524023;揭阳市人民医院麻醉科,广东揭阳 522000
- Keywords:
esketamine;
organ protection;
ischemia reperfusion injury
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(24):3669-3673
- CountryChina
- Language:Chinese
-
Abstract:
Esketamine mainly acts by noncompetitively antagonizing the N-methyl-D-aspartate receptor,and as a dextral isomer of ketamine,it is widely used in clinical practice,especially in anti-inflammatory,analgesic,neuroprotective and other aspects.Esketamine not only has neuroprotective effects,but also has certain organ protective effects.In recent years,more and more studies have shown that ketamine can alleviate organ reperfusion injury by inhibiting cell apoptosis,improving cell damage,and regulating signaling pathways.This article reviews the protective effects and mechanisms of esketamine on the heart,brain,liver and lungs,providing a clinical theoretical basis for the clinical application of esketamine.
