Assessment of diagnostic efficacy on perfluoro butane microsphere ultrasonography in early cirrhosis combined with nodular small cell liver cancer
10.13699/j.cnki.1001-6821.2023.24.008
- VernacularTitle:全氟丁烷微球超声造影对早期肝硬化合并结节状小细胞肝癌诊断效能评估
- Author:
Ping ZHANG
1
;
Qiong ZHOU
;
Zhi-Yong ZENG
Author Information
1. 湖南省人民医院、湖南师范大学附属第一医院超声医学科,湖南长沙 410000
- Keywords:
small cell hepatocellular carcinoma;
ultrasonography;
perfluoro butane microspheres;
cirrhosis;
diagnostic efficacy;
early stage
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(24):3580-3583
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical diagnostic efficacy of perfluoro butane microsphere ultrasonography(S-CEUS)in early cirrhosis combined with nodular small cell hepatocellular carcinoma.Methods Retrospective analysis of all case data of patients with cirrhosis combined with small nodular intrahepatic lesions diagnosed and treated in our hospital,all of whom underwent liver puncture pathological biopsy.Patients were divided into treatment group and control group according to the ultrasound contrast agent.In the control group,0.9％NaCl suspension 5 mL containing 0.03 mL·kg-1 SonoVue was injected into a superficial vein group at the elbow;in the treatment group,perfluoro butane microsphere 0.9％NaCl mixture 5 mL at a dosage of 0.15 μL·kg-1 was given.The overall detection rate and actual diagnostic efficacy of the two groups were analyzed based on liver aspiration pathology biopsy,and safety assessment was performed.Results A total of 127 cases were screened,11 cases were excluded,116 cases were enrolled.There were 52 cases in treatment group and 64 cases in control group.The duration of Kupffer phase in positive and negative subgroups were(84.25±10.23)and(69.11±11.56)min,the difference was statistically significant(P＜0.05).The detection rates of cirrhosis combined with small cell liver cancer in treatment group and control group were 84.62％(44 cases/52 cases)and 70.31％(45 cases/64 cases),the differences were statistically significant(P＜0.05).The AUCs for the diagnosis of cirrhosis combined with small cell hepatocellular carcinoma in treatment group and control group were 0.937(95％CI:0.848-1.027)and 0.894(95％CI:0.797-0.992),both of which had higher diagnostic accuracy.The diagnostic accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of AUC in the treatment group were significantly higher than those in the control group,and the differences were statistically significant(all P＜0.05).Only rash and fever were seen in the two groups,and the overall incidence of adverse drug reactions were 1.92％(1 cases/52 cases)and 3.13％(2 cases/64 cases)in treatment group and control group,respectively,with no statistically significant difference(P＞0.05).Conclusion Perfluoro butane microsphere ultrasonography helps to possess early,and precise identification of cirrhosis combined with nodular small cell liver cancer,which has potential clinical application background and is worthy of clinical recommendation.
