Effect of dexmedetomidine combined with sufentanil on postoperative pain and myocardial enzyme profile in patients with acute myocardial infarction after percutaneous coronary intervention
10.13699/j.cnki.1001-6821.2023.24.003
- VernacularTitle:右美托咪定联合舒芬太尼对急性心肌梗死患者经皮冠状动脉介入治疗术后疼痛和心肌酶谱的影响
- Author:
Shao-Hua CUI
1
;
Xiao-Ling GENG
;
Xiao-Wei YANG
Author Information
1. 内蒙古科技大学包头医学院第一附属医院重症医学科,内蒙古包头 014010
- Keywords:
dexmedetomidine;
sufentanil;
acute myocardial infarction;
percutaneous coronary intervention;
pain;
myocardial zymogram
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(24):3556-3560
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical value of dexmedetomidine combined with sufentanil in patients with acute myocardial infarction(AMI)after percutaneous coronary artery therapy(PCI).Methods A retrospective study was conducted on patients with AMI,and were divided into control group and treatment group according to different treatment plans.Both groups were given PCI.The control group was given sufentanil,and the treatment group was given dexmedetomidine combined sufentanil.Heart rate(HR),mean arterial pressure(MAP),visual analogue scale(VAS)and Ramsay score were compared between the two groups at different times,myocardial enzyme profile indexes(creatine kinase isoenzyme(CK-MB),N-terminal brain natriuretic peptide precursor(NT-proBNP),myoglobin(MYO),troponinⅠ(cTn Ⅰ)were recorded before and 48 h after surgery,and the occurrence of adverse drug reactions in the two groups were recorded.Results A total of 109 patients with AMI were included in this study,including 54 patients in control group and 55 patients in treatment group.In the control group and the treatment group,the initial 25 min HR were(112.32±10.32)and(97.52±11.32)beat·min-1,the MAP were(105.69±8.72)and(101.69±6.87)mmHg,there were significant differences between the two groups(all P＜0.05).The VAS scores at 6,12,24 and 48 h of control group were 4.58±1.12,4.10±0.78,2.32±0.85 and 2.12±0.59,which in treatment group were 4.12±0.32,3.85±0.92,2.02±0.68 and 1.89±0.42,the differences between the two groups were all statistically significant(all P＜0.05).At 48 h after operation,the CK-MB in control group and the treatment group were(149.42±20.78)and(110.49±17.13)ng·mL-1,the NT-proBNP were(1.09±0.42)and(0.92±0.15)ng·L-1,MYO were(78.51±7.85)and(59.42±7.10)pg·mL-1,cTn Ⅰ were(16.78±3.12)and(11.24±2.57)pg·mL-1,there were statistically significant differences between the two groups(all P＜0.05).There was no significant difference in the incidence of adverse drug reactions between treatment group(9.09％)and the control group(5.56％,P＞0.05).Conclusion Dexmedetomidine combined with sufentanil in the treatment of AMI patients after PCI can improve hemodynamic indexes,and reduce postoperative pain,myocardial enzyme spectrum,and have good safety.
