Research status of epithelial-mesenchymal transition in idiopathic pulmonary fibrosis
10.13699/j.cnki.1001-6821.2023.23.034
- VernacularTitle:特发性肺纤维化中上皮-间质转化的研究现状
- Author:
Ya-Na WU
1
;
Dong-Ling LIU
;
Zhong-Yang SONG
;
Da HUANG
;
Peng ZHU
;
Qian XU
;
Zhi-Ming ZHANG
Author Information
1. 甘肃中医药大学中医临床学院,甘肃兰州 730000;甘肃中医药大学附属医院急诊科,甘肃兰州 730000
- Keywords:
idiopathic pulmonary fibrosis;
alveolar epithelial cell;
fibroblasts/myofibroblasts;
macrophages cell;
epithelial-mesenchymal transition;
fibrosis factor
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(23):3499-3503
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis(IPF)is a refractory disease,which seriously endangers the health of patients and increases the mortality of patients.Its pathogenesis is still unclear,but it is mainly driven by alveolar epithelial cell injury.Epithelial-mesenchymal transition is an important part of the disease and is considered to be a potential therapeutic target.A series of in vitro and in vivo experiments have confirmed the role in IPF.This article reviews the interaction mechanisms of IPF-related cells and fibrosis factors in IPF,in order to provide a theoretical basis for further exploration of the occurrence and development mechanism of IPF and future clinical prevention and treatment.
