Effect of clarithromycin tablets on the pharmacokinetics of bicalutamide tablets in rabbits
10.13699/j.cnki.1001-6821.2018.19.027
- VernacularTitle:克拉霉素片对比卡鲁胺片在兔体内药代动力学的影响
- Author:
Yong-Hai LOU
1
;
Mi-Mi GUAN
;
Xiao-Long LIANG
;
Ye LI
;
Wan-Jun ZHANG
;
Xu-Yi YANG
Author Information
1. 浙江省台州医院 药剂科
- Keywords:
bicalutamide tablet;
clarithromycin tablet;
HPLC;
pharmacokinetics
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(19):2339-2341,2351
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of clarithromycin on the phar-macokinetics of bicalutamide in rabbits .Methods Six New Zealand white rabbits were randomly divided into control group and test group , with 3 rabbits in each group.The control group was given bicalutamide 50 mg by gavage.The test group was given bicalutamide 50 mg +cla-rithromycin 250 mg by gavage , and blood samples were collected at di-fferent time points.After 3 weeks, a crossover test was performed.Bi-calutamide plasma concentration was detected by HPLC .The pharmacoki-netic parameters of bicalutamide were calculated using DAS 2.0 softwareand statistical analysis was performed using SPSS 20.0 software.Results The AUC0-∞of the test and control groups were ( 217.57 ±60.74 ) and (175.39 ±16.64) mg· L-1· h, MRT0-∞were ( 65.76 ±4.81 ) and (62.82 ±3.09)h, t1/2were (53.14 ±9.02) and (48.67 ±5.51) h, Cmax were ( 3.47 ±1.14 ) and ( 2.85 ±0.34 ) mg · L-1, CL/F were (0.24 ±0.05)and (0.29 ±0.03)L· h-1.AUC0-∞, t1/2, and Cmaxwere not statistically different (all P>0.05).MRT0-∞and CL/F were statistically significant (all P<0.05).Conclusion Clarithromycin reduces the clearance rate of bicalutamide in rabbits and prolongs the average residence time.
