Genetic polymorphism distribution of associated with carbamazepine therapy in healthy volunteers of Han Chinese
10.13699/j.cnki.1001-6821.2018.10.031
- VernacularTitle:卡马西平治疗相关基因的基因多态性在中国汉族健康受试者中的分布研究
- Author:
Liu-Shui LI
1
;
Bin-Bin XIA
;
Rui XIA
;
Qian HE
;
Xiang LI
;
Shi-Cai CHEN
Author Information
1. 首都医科大学附属北京潞河医院临床药学中心
- Keywords:
carbamazepine;
healthy volunteers of Han Chinese;
gene polymorphism;
genotype distribution
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(10):1246-1249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To survey the genetic polymorphism distribution of cytochrome P(CYP) 3A4 * 1 B,CYP 3A4 * 1G,CYP 3A5 * 3,human leukocyte antigen(HLA)-B * 1502 gene associated with carbamazepine therapy in healthy volunteers of Han Chinese.Methods A total of 187 Han Chinese healthy volunteers were randomly selected and their related genotypes were analyzed by fluorescence in situ hybridization.Statistical analysis was performed.Results CYP 3A4 * 1 B loci were all AA genotype (100％).The genotypes of CC,CT and TT in CYP 3A4 * 1G gene locus accounted for 62.57％,34.22％ and 3.21％,respectively;GG,AG and AA genotypes in CYP3A5 * 3 locus accounted for 58.29％,34.76％ and 6.95％;the CC and CG genotypes in HLA-B * 1502 locus accounted for 89.30％ and 10.70％ respectively,but no GG genotype was found.Conclusion The CYP 3A4 * 1 B,CYP3A4 * 1 G,CYP 3A5 * 3 and HLA-B * 1502 gene polymorphisms were more common in Chinese Han healthy volunteers,the mutation rate was high,and some of the results were consistent with the previous researches,also there was a significant difference in the results with some other populations.
