Chemotherapeutic effect of gemcitabine for non-small cell lung cancer patients and the correlation with the expression of gene in pathological tissue
10.13699/j.cnki.1001-6821.2018.07.017
- VernacularTitle:吉西他滨对非小细胞肺癌患者化疗疗效与其病理组织基因表达的相关性
- Author:
Lin-Lin LI
1
;
Bao-Li XIANG
;
Qian-Long XUE
;
Jian-Hua LIU
Author Information
1. 河北北方学院附属第一医院急诊科
- Keywords:
non-small cell lung cancer;
gemcitabine;
chemotherapy;
ribonucleotide reductase M1;
excision repair cross-complementing 1
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(7):793-795,799
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the chemotherapeutic effect of gemcitabine for non-small cell lung cancer patients and analyzed the correlation of chemotherapeutic effect with ribonucleotide reductase M1 (RRM1),excision repair cross-complementing 1 (ERCC1) expression in pathological tissue.Methods The clinical data of 96 non-small cell lung cancer patients were selected.All patients were treated with gemcitabine + cisplatin chemotherapy,and the RRM1,ERCC1 expression in pathological tissue were detected by immunohistochemical method at 3 weeks after chemotherapy,the correlation of clinical features with chemotherapeutic effect were analyzed.Results The positive expression rates of RRM1 and ERCC1 were 60.42％,43.75％.The positive expression of non-small cell lung cancer patients pathological tissue RRM1,ERCC1 had significant correlation with the gender and smoking status (P ＜0.05 or P ＜0.01),while had no correlation with the age and clinical stages (all P ＞0.05).The effective rates of patients with pathological tissue RRM1/ERCC1 +/+,-/-,+/-or-/+ were 17.95％,74.29％ and 59.09％,and the effective rates of patients with pathological tissue RRM1/ERCC1-/-were higher than +/ +,+/-or-/+ (P ＜0.05 or P ＜ 0.01),and the effective rates of patients with pathological tissue RRM1/ERCC1 + /-or-/ + were higher than RRM1/ERCC1 + / + (all P ＜ 0.05).Spearman correlation analysis showed that,the negative expression of non-small cell lung cancer patients anthological tissue RRM1,ERCC1 had significant positive correlation with chemotherapeutic effect (r =0.248,0.306,all P ＜ 0.05).Conclusion Gemcitabine has a certain clinical effect in the treatment of non-small cell lung cancer patients,and the clinical effect had significant positive correlation with the negative expression of non-small cell lung cancer patients anthological tissue RRMl,ERCC1 protein,which can act as the evaluation index for the chemotherapeutic effect.
