Association between catechol-O-methyl transferase Val158Met polymorphism and breast cancer susceptibility
10.13699/j.cnki.1001-6821.2018.06.008
- VernacularTitle:儿茶酚-O-甲基转移酶基因Val158Met多态性与乳腺癌易感性关系研究
- Author:
Shu-Bo LI
1
;
Zhang-Xiu LIAO
;
Ying LUO
;
Shan HE
;
Gen-Liang LI
;
Yao LIN
Author Information
1. 右江民族医学院基础医学院
- Keywords:
catechol-O-methyl transferase;
Val158Met;
gene polymorphism;
breast cancer;
susceptibility
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(6):636-639
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether single nucleotide polymorphisms of catechol-O-methyl transferase (COMT) of Val158Met are associated with the risk of breast cancer.Methods Gene polymorphisms of COMT were detected using di-allele-specific-amplification with artificially modified primers combined with SYBR Green I real-time polymerase chain reaction in a case-control study,which included 96 breast cancer patients (treatment group) and 116 healthy women(control group).Results The frequency of allele G in COMT gene Val158Met was 65.10％ and 71.98％ in treatment group and control group,and the frequency of allele A were 34.90％ and 28.02％ respectively.There were no differences between the two groups in allele frequencies of COMT Val158Met among Guangxi Baise population (all P ＞ 0.05).COMT Val158Met G/G genotype frequency distribution of the treatment group (38.54％) was lower than that of control group (54.31％),A/G genotype frequency distribution of the treatment group was higher(53.13％)than that of control group (35.34％).The distribution frequency differences of the two groups homozygous wild-type and heterozygous were statistically significant (all P ＜ 0.05).A/A genotype frequency distribution was relatively similar in the treatment group and control group,and they were 8.33％ and 10.35％ respectively.The breast cancer risks of Guangxi Baise women with A/G heterozygous genotype increased by 2.118 times compared with that of G/G homozygous genotype.Conclusion Gene polymorphism of COMT Val158Met may be associated with the risk of breast cancer.
