Comparative imaging study of two positron emission computed tomography tracers of 18F-FEA-Erlotinib and 11C-Erlotinib in HCC827 tumor-bearing nude mice
10.13699/j.cnki.1001-6821.2018.05.014
- VernacularTitle:正电子发射型计算机断层显像剂18F-FEA-Erlotinib与11C-Erlotinib在HCC827荷瘤小鼠中的显像效果对比研究
- Author:
Shun HUANG
1
;
Yan-Jiang HAN
;
Kong-Zhen HU
;
Li CHEN
;
Peng-Hui SUN
;
Hu-Bing WU
;
Quan-Shi WANG
;
Su-Qing ZHAO
;
Xi ZHENG
Author Information
1. 广东工业大学 轻工化工学院
- Keywords:
non-small cell lung cancer;
HCC827 cell;
18 F-flouroetingl-Erlotinib;
11C-Erlotinib;
positron emission computed tomography imaging
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(5):535-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the imaging study of two positron emission computed tomography (PET) tracers of 18 F-fluoroethyl (FEA)-Erlotinib and 11C-Erlotinib in HCC827 tumor-bearing nude mice.Methods The 18F-FEA-Erlotinib and 11C-Erlotinib were synthesized by nucleophile substitution reactions.The dynamic micro-PET/CT imaging of 18F-FEA-Erlotinib for 1 h was performed in HCC827 tumor -bearing mice to evaluate the in vivo biological distribution and determine the best imaging time.Static scan of 18 F-FEA-Erlotinib and 11C-Erlotinib were performed after 1 h injection.The regions of interest (ROIs) were sketched and the semi-quantitative analysis was conducted by the percentage activity of injection dose per gram of tissue (％ ID/g).Results Dynamic micro-PET/CT imaging analysis revealed that the best static imaging time was 1 h.The resolution and contrast were good and the tumor boundaries were clear in the 18F-FEA-Erlotinib static images.In the semi-quantitative analysis,the ratios of tumor/brain,tumor/lung,tumor/bone and tumor/muscle ratios were 5.87 ± 1.21,2.97 ± 0.58,3.33 ± 0.60 and 3.80 ± 0.72 respectively for 18F-FEA-Erlotinib.Meanwhile,the ratios of the same tissues were 5.48 ± 1.45,1.10 ± 0.34,2.63 ± 0.54 and 2.10 ± 0.63respectively for 11C-Erlotinib.The resolution of 18F-FEA-Erlotinib imaging was better than 11C-Erlotinib images.Conclusion The uptake of 18F-FEA-Erlotinib in HCC827 tumor was visual obviously.The image resolution and the target/non-target ratio of 18F-FEA-Erlotinib was higher than 11C-Erlotinib.
