Review of posaconazole on pharmacokinetic impact of immunosuppressors
10.13699/j.cnki.1001-6821.2018.01.015
- VernacularTitle:泊沙康唑对免疫抑制药药代动力学影响的评价
- Author:
Hong-Mei WANG
1
;
Ken CHEN
;
Kai HU
;
Wei LIU
Author Information
1. 北京大学第三医院延庆医院、北京市延庆区医院药剂科
- Keywords:
posaconazole;
cyclosporine;
tacrolimus;
sirolimus;
drug-drug interaction
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(1):57-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate pharmacokinetic impact of posaconazole on immunosuppressors.Methods PubMed,EmBase,Cochrane Library Clinicaltrials.gov,CNKI,Wanfang data and CBM were systematica-lly searched.Randomized controlled trials and observational studies which compared combinational use of immunosuppressors and posaconazole were collected.If necessary,Meta-analysis about pharmacokinetic characters of immunosuppressors were performed with RevMan 5.3 software.Results Totally 7 studies were included,involving 258 patients.Two studies of them involving 45 patients related to cyclosporine,3 studies involving 62 patients were using tacrolimus,and 4 studies of 151 patients studied sirolimus,respectively.Overall quality of included studies was low.Concentration/dosage ratio (C/D),AUC,Cmax and t1/2 of cyclosporine when combined with posaconazole were 1.38-told,1.33-fold,1.05-fold and 1.21-fold increase when compared with cyclosporine A monotherapy C/D,AUC,Cmax and t1/2 of tacrotimus were 3.29-fold,4.23-fold,2.14-fold and 1.24-fold increase compared with monotherapy.C/D,AUC,Cmax and t1/2 of sirolimus were 2.71-fold,8.34-fold,6.37-fold and 1.52-fold increase compared with monotherapy.Conclusion Pharmacokinetics of immunosuppressors were changed when combined with posaconazole,therefore dosage should be adjusted according to therapeutic drug monitoring.
