Study on minimum inhibitory concentrations and its influence factors of cefathiamidine
10.13699/j.cnki.1001-6821.2018.01.007
- VernacularTitle:头孢硫脒最低抑菌浓度及其影响因素研究
- Author:
Feng XUE
1
;
Yun LI
;
Yuan L(U)
;
Jian LIU
;
Wei-Wei YANG
;
Jia ZHANG
Author Information
1. 北京大学第一医院临床药理研究所
- Keywords:
cefathiamidine;
in vitro antibacterial activity;
minimum inhibitory concentration;
Enterococcus spp.
- From:
The Chinese Journal of Clinical Pharmacology
2018;34(1):25-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the minimum inhibitory concentration (MIC) and influence factors of cefathiamidine against clinical isolates from recent years in China.Methods MIC were tested by two fold agar dilution method.The effect of various experimental conditions (such as inoculation quantity,pH value of medium,percentage of serum)on MIC of cefathiamidine was evaluated.Results A total of 794 clinical strains were tested and cefathiamidine had showed excellent antibacterial activity against gram-positive bacterial.The MIC90 of cefathiamidine against methicillin-susceptible S.aureus (MSSA) and S.epidermidis (MSSE)were 0.50,0.12 mg · L-1,respectively.The MIC90 values of cefathiami-dine had against penicillin-susceptible S.pneumoniae (PSSP) and peni-cillin-nonsusceptible S.pneumoniae(PNSSP) were 0.12 mg· L-1 and not more than 1 mg · L-1,respectively.Against S.pyogenes,the MIC90 was 8 μg · L-1.The MIC90 of cefathiamidine against ampicillin-susceptible E.faecalis and E.faecium were 1,16 mg · L-1,respectively.The MIC90 of cefathiamidine against ampicillin-susceptible Haemophilus spp.and Moraxella catarrhalis were not more than 4 mg L-1 Cefathiamidine also had some antibacterial activity against gram-positive anaerobia.The factors including inoculation quantity,pH value of medium and percentage of serum had no effect on MIC values.Conclusion Cefathiamidine exhibited good activity against gram-positive bacterial including Enterococcus spp..
