Optimization of β lactam antibiotics regimens against bloodstream infection caused by Pseudomonas aeruginosa
10.13699/j.cnki.1001-6821.2017.24.018
- VernacularTitle:β内酰胺类在铜绿假单胞菌血流感染中的方案研究
- Author:
Chun-Hua LI
1
;
Yu-Lan QIAN
;
Di YU
;
Yan-Ping LI
;
Yong-Fu HANG
Author Information
1. 苏州大学附属第一医院药学部,江苏苏州215006
- Keywords:
β lactam antibiotics;
Pseudomonas aeruginosa;
bloodstream infection;
monte carlo
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(24):2621-2623
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop the regimens of β lactam antibiotics against bloodstream infection caused by Pseudomonas aeruginosa (PA).Methods A total of 64 strains of PA cultured by blood from 2015 to 2016,the minimum inhibitory concentration (MIC) of piperacillin/tazobactam (TZP),ceftazidine (CAZ),cefepime (FEP),imipenem (IPM),meropenem (MEM) against PA were determined,probability of target attainment (PTA) and cumulative fraction of response (CFR) were calculated by monte carlo simulation.Results CFRs of TZP 4.5 g (q6 h),CAZ 2 g(q8 h),FEP2 g(q8 h),IPM 1 g(q6 h) and MEM 1 g (q8 h,q6 h) were ＞ 90％ at experiential therapy,when MIC ≥ 16 μg· mL-1 at target therapy,PTA of all regimens ＜90％.Conclusion when the patient was PA bloodstream infection,we suggest TZP 4.5 g (q6 h),CAZ2 g(q8 h),FEP2 g(q8 h),IPM 1 g(q6 h) and MEM 1 g (q8 h,q6 h) regimens at experiential therapy,and combined with other antibiotics at target therapy when MIC ≥ 16 μg · mL-1.
