Recent progress of gene polymorphisms in the formation of venous thromboembolism in different ethnic groups
10.13699/j.cnki.1001-6821.2017.23.050
- VernacularTitle:多基因突变在不同种族人群深静脉血栓形成中的研究现状
- Author:
An-Na MENG
1
;
Han XIE
;
Chang-Qing YANG
;
Wei-Hong GE
;
Hang XU
Author Information
1. 南京大学医学院附属鼓楼医院药学部,南京210008
- Keywords:
factor V Leiden;
factor Ⅱ G20210A;
methylene tetrahydrofolate reductase;
plasminogen activator inhibitor-type 1;
venous thromboembolism
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2497-2500
- CountryChina
- Language:Chinese
-
Abstract:
Venous thromboembolism,a semi-solid embolus formed as the result of blood coagulation in the vein system,is caused by the destruction of the balance between the fibrinolysis and thrombosis.Meanwhile,venous thromboembolism is a multivariate disease influenced by herediqtary and acquired risk factors.The gene polymorphisms of factor V Leiden (FVL),factorⅡ G20210A(F Ⅱ G20210A),methylene tetrahydrofolate reductase C677 T(MTHFR),and plasminogen activator inhibitor-type 1 (PAI-1) were the common molecular biomarkers that can be used to assess the risk of VTE.Taking regional differences of these gene polymorphisms into consideration,the recent progress of the four gene polymorphisms in different ethnic population was reviewed.
