Research progress on the role of antidiabetic drugs in treatment of cognitive deficits in patients with Alzheimer's disease
10.13699/j.cnki.1001-6821.2017.23.049
- VernacularTitle:糖尿病治疗药物改善阿尔兹海默病患者认知障碍的研究现状
- Author:
He ZHAO
1
;
Hua SHAO
;
Yi-Min NIU
;
Feng YU
Author Information
1. 中国药科大学基础医学与临床药学学院,南京210000;东南大学附属中大医院药学部,南京210009
- Keywords:
Alzheimer's disease;
cognitive deficits;
type 2 diabetes mellitus;
antidiabetic drug
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(23):2493-2496
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD)and type 2 diabetes mellitus (T2DM),causing by population ageing and changing lifestyles,have become latest threats to human health.Recent basic researches and clinical studies suggested that T2DM was a risk factor for cognitive impairment and dementia.Brain insulin signaling impairment and insulin metabolic disorders are often associated with patients with AD,indicating T2DM and AD share similar signaling pathways during pathological development.Therefore,the underlying mechanism involved in cognitive improvement of antidiabetic drugs (including insulin,glucagon-like peptide-1,thiazolidinediones and dipeptidyl peptidase-4 inhibitors) for AD patients are discussed in this review.
