Progress in gene polymorphisms related to lipid metabolic side effects of atypical antipsychotics
10.13699/j.cnki.1001-6821.2017.13.032
- VernacularTitle:非典型抗精神病药物致脂代谢不良反应的基因多态性研究进展
- Author:
Na-Ha LI
1
;
Yan-Qin WU
;
Pei JIANG
;
Qin-You TAN
;
Ping XU
;
Huan-De LI
;
Hua-Lin CAI
Author Information
1. 中南大学湘雅二医院药学部
- Keywords:
atypical antipsychotic drugs;
weight gain;
lipid metabolism disorders;
pharmacogenomics;
single nucleotide polymorphisms
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(13):1284-1287
- CountryChina
- Language:Chinese
-
Abstract:
Adverse reactions like weight gain and lipid metabolism disorders are often observed in the treatment of atypical antipsychotic drugs,which have shown great individual differences,but the mechanism is still uncertain.Research on pharmacogenomics indicate that gene polymorphism may play an important role.The drugs could increase food intake by acting on some related central receptors,or effect lipid metabolism in the adipose cell and hepatocyte.In this review,genes and polymorphisms related to lipid metabolic adverse drug reactions of atypical antipsychotic drugs were analyzed in these two aspects,so as to provide references for individualized medication and research.
