Pharmacokinetics and tissue distribution of compound anisodine in rabbits
10.13699/j.cnki.1001-6821.2017.08.015
- VernacularTitle:复方樟柳碱注射液在家兔体内的药代动力学及组织分布研究
- Author:
Qi XU
1
;
Xiu-Li ZHAO
;
Si-Yang NI
;
Xiao-Lei REN
;
Ke MA
;
Liang-Ping YAN
;
Hong-Wei LIU
;
Feng WU
Author Information
1. 首都医科大学附属北京同仁医院国家药物临床试验机构
- Keywords:
compound anisodine;
LC-MS/MS;
pharmacokinetics;
tissue distribution
- From:
The Chinese Journal of Clinical Pharmacology
2017;33(8):726-729
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pharmacokinetics and tissue distribution characteristics of compound anisodine (CA) in rabbits.Methods Rabbits were injected with 0.7 mL · kg-1 CA subcutaneously around superficial temporal artery,and LC-MS/MS method was used to determine the concentration of anisodine hydrobromide and procaine hydrochloride in plasma and tissues.The pharmacokinetic parameters were calculated by WinNonlin 6.2 software.Results Main pharmacokinetic parameters of anisodine and procaine were as follows:Cmax were (12.93 ± 1.90),(895.47 ±213.99)ng · mL-1;tmaxwere (0.35 ±0.18),(0.24±0.15)h;t1/2were (0.82 ±0.22),(0.49±0.11)h;AUC0-t were (19.20 ± 5.71),(706.59 ± 121.90) ng · mL-1 · h,respectively.The concentration of anisodine was higher in the retina and choroid,kidney,and lung,and procaine was distributed more in the retina and choroid,spleen,and kidney.Conclusion CA are rapidly absorbed with short half-life and extensive distribution.
