Study on genetic polymorphisms of cytochrome P450 24A1 in healthy Han Chinese population

VernacularTitle:中国汉族健康人群CYP24A1的基因多态性研究
Author: Xiao-Zhen LIN ¹ ; Bao-Xia HE ; Xiu-Li ZHAO ; Wen-Zhou ZHANG ; Hong-Xia LI ; Feng-Qi TIAN ; Juan DU ; Wei YANG ; Wei-Jiang YU ; Bin ZHANG
Author Information

1. 郑州大学附属肿瘤医院、河南省肿瘤医院药学部
Keywords: cytochrome P450 24A1; genetic polymorphisms; distribution frequency
From: The Chinese Journal of Clinical Pharmacology 2017;33(6):493-495
CountryChina
Language:Chinese
Abstract: Objective To detect the polymorphisms and haplotype of 25 -hydroxyvitamin-D3-24-hydroxylase (CYP24A1) in Chinese healthy Han population.Methods Two hundred and three Chinese Han healthy volunteers were entrolled in this study.Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF -MS) was used to identify the polymorphisms of CYP24A1.The haplotype frequencies were analyzed by Phase 2.1.Results The frequency distribution of CYP24A1 rs1570669,rs34043203,rs3787557,rs6068816 were 36.0％,16.3％,24.4％,31.5％.The frequency distribution of GCTT,GCTC,GCCC,ATTC in CYP24A1 haplotype were 27.7％,17.2％,14.3％,12.5％.Conclusion The frequencies of these variants were high in Chinese healthy Han population.The frequency of GCTT haplotype was high as well.