Comparison the effect of the two models of neuropathic pain

VernacularTitle:大鼠神经病理痛模型的两种不同制备方法效果比较
Author: Xiang-Dong WANG ¹ ; Li-Ping WAN ; Qing LI ; Xiao-Dan ZHANG ; Jie ZHOU ; Ceng-Xu LIU
Author Information

1. 江西卫生职业学院
Keywords: neuropathic pain; rat model; constriction injury of the sciatic nerve
From: The Chinese Journal of Clinical Pharmacology 2016;32(8):707-709
CountryChina
Language:Chinese
Abstract: Objective To establish the chronic constriction injury model (CCI)rat model by catgut(group A)and by catgut including the needle ( group B) and compare the effects of two methods.Methods Fourty-five SD rats were randomized into sham-operated group, group A and group B.The mechanical with drawl threshold( MWT) and thermal with drawl latency( TWL) were measured to detect the effect of CCI rat model on the day of 7, 9, 11, 13, 15, 17, 19, 21 after operation.Results The mechanical and thermal pain threshold in group A and group B were both lower than those in sham -operated group ( P <0.01 ) , which showed the success of CCI model.The success rate in group B was higher than that in group A and the mechanical with drawl threshold significantly decreased than that in group A ( P<0.01).Conclusion The rat model of neuropathic pain could be prepared by two methods, but group B were significantly better than group A.