Clinical study of alanyl glutamine on chemotherapy -induced oral mucositis in patients with malignant lymphoma
10.13699/j.cnki.1001-6821.2016.06.028
- VernacularTitle:丙氨酰谷氨酰胺对恶性淋巴瘤化疗后口腔炎的临床疗效研究
- Author:
Wu-Cha ZENG
1
;
Xi SHI
;
Li-Ming HUANG
;
Yu-Jie DENG
Author Information
1. 福建医科大学 附属第一医院 化疗科
- Keywords:
malignant lymphoma;
chemotherapy;
oral mucositis;
sodium bicarbonate;
alanyl glutamine
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(6):567-569
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of alanyl glu-tamine injection on the prevention and treatment of chemotherapy -in-duced oral mucositis in patients with malignant lymphoma.Methods A total of 130 cases suffering from chemotherapy of malignant lymphoma were divided into treatment group(n=65) and control group(n=65).Both groups were given sodium bicarbonate solution gargled.Patients in control group were given 12.5% sodium bicarbonate solution gargle, 3 times a day.And patients in treatment group were given alanine gluta-mine injection 20 g· d -1 for 1 week on the basis of control group.After the chemotherapy cycle, the incidence of oral mucositis and stomatitis cure time were compared between the two groups.Results The chemo-therapy-induced oral mucositis rate were 35.38%and 46.15%in treat-ment group and control group, with statistical difference( P<0.05).The cure time for grade Ⅲ chemotherapy -induced oral mucositis were (8.25 ±0.96), ( 11.17 ± 1.47 ) d, with statistical difference ( P<0.05).There was no drug related adverse reaction during the treat-ment.Conclusion Alanyl glutamine injection combined with sodium bi-carbonate gargled has a significantly preventive and therapeutic effect on chemotherapy-induced oral mucositis in patients with malignant lymphoma.
