Rationality of developing fixed -dose combination of aspirin and proton pump inhibitor
10.13699/j.cnki.1001-6821.2016.05.026
- VernacularTitle:阿司匹林和质子泵抑制剂固定复方制剂的立题合理性探讨
- Author:
Wei-Xian XU
1
;
Ying CHEN
;
Wei-Li HUA
;
Song-Mei XIE
;
Tao WANG
;
Shui-Qiang WANG
Author Information
1. 北京大学 第三医院 心血管内科
- Keywords:
aspirin;
proton pump inhibitor;
fixed -dose combination;
benefit/risk
- From:
The Chinese Journal of Clinical Pharmacology
2016;32(5):466-468
- CountryChina
- Language:Chinese
-
Abstract:
Low-dose aspirin (75-150 mg· d-1 ) is widely used in the management of ischemic cardiovascular and cerebrovascular diseases.As-pirin can cause gastrointestinal mucosal damage , ulceration and blee-ding.Proton pump inhibitor ( PPI) is a strong and long-last inhibitor of gastric acid secretion.In patients with long-term use of low-dose aspi-rin, PPI can be added for short time in the event of serious upper gastro-intestinal adverse reactions according to the clinical conditions.The ra-tionality of developing fixed -dose combination of aspirin and PPI is discussed in this paper.When the possible benefit/risk is taken into account , the basis for the developing fixed -dose combination of aspirin and PPI is insufficient.
