Considerations of development and evaluations for antihypertensive fixed -dose single-pill combinations
10.13699/j.cnki.1001-6821.2016.03.029
- VernacularTitle:抗高血压复方药物合理研发及评价的考虑
- Author:
Wei-Xian XU
1
;
Tao WANG
;
Shui-Qiang WANG
;
Cai-Lian KANG
;
Wei-Li HUA
;
Hong-Yan ZHAO
;
Song-Mei XIE
Author Information
1. 北京大学 第三医院 心血管内科
- Keywords:
antihypertensive drug;
fixed-dose single-pill combinations
- From:
The Chinese Journal of Clinical Pharmacology
2016;(3):286-288
- CountryChina
- Language:Chinese
-
Abstract:
Combination therapy is an important principle of antihyperten-sive therapy for the patients whose blood pressure is not well controlled by single antihypertensive therapy.Fixed -dose single -pill combinations can improve the compliance of patients with respect to the free combina-tion of antihypertensive drugs in some cases , but it is not convenient to adjust the categories and doses of the drugs in the clinical practice.Therefore , the key points of the developing rationality , technical consi-derations of clinical development and evaluations and the monitoring of regulatory authorities will be discussed in this paper in order to provide reference for the developing antihypertensive drugs in rational and scien-tific ways.
