Efficacy and safety of modified electroconvuisive combined with paroxetine in the treatment of depression with attempted suicide
10.13699/j.cnki.1001-6821.2016.02.019
- VernacularTitle:帕罗西汀联合无抽搐电休克治疗伴自杀倾向抑郁症的临床疗效及安全性
- Author:
Li-Ming CHEN
1
;
Li KUANG
;
Da-Qi LI
;
Dai-Jiang ZHANG
;
Yun-Yue HOU
Author Information
1. 重庆医科大学 附属第一医院 心理卫生中心
- Keywords:
depression;
modified electroconvuisive therapy;
paroxetine;
Hamilton depression scale
- From:
The Chinese Journal of Clinical Pharmacology
2016;(2):153-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of modified electroconvuisive therapy combined with paroxetine in the treatment of depression patients with attempted suicide andprovide the basis for clinical treatment.Methods A total of 128 cases of depression patients with attempted suicide were divided into treatment group ( n =64 ) and control group ( n =64 ).Patients in treatment group were treated with modified electroconvuisive therapy combined with paroxetine , 3 times per week , 12 times totally , and patients in control group were treated with paroxetine, 30-40 mg· d-1 , once a day for 4 weeks.Before and after treatment, Hamilton depression(HAMD) scale, Beck score, and adverse reactions of the two groups were observed , the efficacy and safety of two groups were evaluated.Results After treatment 1 week, the HAMD and Beck score of the patients in treatment group were ( 19.65 ±7.43 ) and (9.19 ±3.47 ), respectively, significantly better than those of control group (24.62 ±4.57 ),(12.43 ±5.28 ).In the following 2 -4 weeks after treatment, the HAMD and Beck score of treatment group were also better than control group.The effective rate in treatment group (96.9%)was higher than that in control group (90.6%,P<0.05).The complete recovery rate in treatment group is 62.5%, which was higher than 34.4%in control group ( P<0.05 ).The incidence rate of adverse reactions in treatment group and control group were 6.25%, 9.38%, respectively , the difference had no statistical significance ( P >0.05 ).Conclusion Modified electroconvuisive therapy combined with paroxetine in the treatment of depression patients with attempted suicide is superior to the single effect of paroxetine, and does not increase the risk of adverse reactions.
