Pharmacokinetics of ion-exchange microsphere loaded with pingyangmycin

VernacularTitle:载平阳霉素离子交换型微球的药代动力学研究
Author: Jie GAO ¹ ; Xuan LI ; Er-A SA ; Tian-Yuan FAN
Author Information

1. 北京大学第三医院放射科
Keywords: pingyangmycin; microspheres; pharmacokinetic; embolism
From: The Chinese Journal of Clinical Pharmacology 2015;(3):203-205,211
CountryChina
Language:Chinese
Abstract: Objective To investigate the characteristics of pharmacoki-netics of pingyangmycin ion -exchanged microspheres in rabbits.Methods A total of 12 Japanese rabbits, half male and half female, were randomly divided into group A and group B.The rabbits in group A and group B were injected with PYM and PYM-MS via external carotid artery separately.The blood samples were obtained at 2, 5, 10, 20, 40, 60 ,90 and 120 minutes after injection and detected by HPLC method.The parameters of pharmacokinetics were analyzed.Results Compared with group A, it showed a slow decrease in terms of concentration-time curves of pingyangmycin in rabbits after administration of PYM-MS in group B;the Cmax [(11.62 ±2.66) vs (58.96 ±4.51) mg· L-1 ] and AUC [(21.06 ±31.33) vs (791.98 ±55.30) mg· L-1 · min] in group B were significantly lower ( P <0.01 ) , but the data of MRT0-60 min was longer in group B [ ( 22.29 ±1.52 ) vs ( 14.20 ±1.24 ) min ] , P <0.01.Conclusion PYM-MS showed definite property of delayed drug release, with a lower plasma concentration.