Analgesia effects and safety of dexmedetomidine on patients undergoing combined hysteroscopy and laparoscopy
10.13699/j.cnki.1001-6821.2015.02.003
- VernacularTitle:右美托咪定对宫腹腔镜手术患者镇痛疗效与安全性的研究
- Author:
Chen YU
1
;
Dong-Lin JIA
;
Xiao-Qing ZHANG
;
Li-Juan KONG
;
Yue-Xin LI
;
Yan YANG
;
Jun WANG
Author Information
1. 北京大学 第三医院 麻醉科
- Keywords:
dexmedetomidine;
combined hysteroscopy and laparoscopy surgery;
sedation;
analgesia
- From:
The Chinese Journal of Clinical Pharmacology
2015;(2):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of dexmedetomidine on patients undergoing combined hysteroscopy and laparoscopy . Methods Ninety patients undergoing combined hysteroscopy and lapa-roscopy were randomly divided into control group ( C ) , dexmedetomidine group1 ( D1 ) and dexmedetomidine group 2 ( D2 ) , with thirty patients each.Dexmedetomidine 0.4 μg · kg -1 was injected in each patient in group D1 and D2 intravenously in 10 min by infusing pump after induc-tion of anesthesia , while an equal volume of 0.9%NaCl was administered to patients in group C.Peri-operative mean arterial pressure (MAP), heart rate ( HR) , bispectral index ( BIS ) , operation time , and extuba-tion time were recorded.The intensity of pain was valued using visual analogue scale ( VAS) at 2, 4, 12, 24 h after operation.The adverse effects and the usage of analgesic drugs were recorded.Results Hemo-dynamic parameters were more stable during operation in group D 1 and D2 than those in group C , and BIS of group D1 and D2 were lower than that of group C.Extubation time of group D 1 was longer than that in group C , while there was no significant difference in extubation time be-tween group D2 and C.Compared with group C ,the data of VAS in group D1 and D2 were decreased , with less adverse reaction and usage of anal-gesic drugs.Conclusion Dexmedetomidine 0.4 μg · kg -1 injected intravenously can reduce the doses of drugs for anesthesia maintenance in patients undergoing combined hysteroscopy and laparoscopy , without a prolongation of extubation time , but can release postoperative pain , decrease the incidence of nausea , vomiting and shivering , and will save postoperative analgesics.
